Carel Wynand le Roux

Prof. Carel Wynand le Roux MBChB, MSc, FRCP, FRCPath, PhD 

PRIZES AND AWARDS:

  1. Graves medal, Royal College of Physicians of Ireland (2015)
  2. International Federation for Clinical Chemistry visiting lecturer award (2014)
  3. Nicola Scopinaro lecture, International Federation for Surgery of Obesity, New Delhi (2012)
  4. Steno medal, Steno Centre, Denmark (2011)
  5. Trinity College Dublin innovation in Diabetes Medal (2011)
  6. Young Investigator: European Association for Study of Obesity (2008)
  7. Alberta Heritage Foundation for Medical Research Lecturer Award (2008)
  8. Cuthbertson Medal for achievements in nutrition, Nutrition Society (2008)
  9. Young Investigator Award: Association for Study of Obesity (2007)  

Address: 11B Friars Way

London W3 6QF

Telephone: +44 (0)7970719453

e-mail: carel.leroux@nhs.net

Date and place of birth: 31/08/1972, Pretoria, South Africa

Citizenship: Irish and South African

 

Medical Council of Ireland 406133

General Medical Council: 4366094

Medical Protection Society: SA 23379

Languages: Fluent in English, Dutch and Afrikaans

 

Degrees: MBChB (University of Pretoria),

MSc (University of London),

FRCP (UK),

FRCPath

FFPath (Royal College of Physicians in Ireland)

PhD (Imperial College London)

GRANTS

 

  1. Irish Research Council. 2018-2022. Mechanism of unintentional weight loss. €600,000 (Principal Investigator)
  2. European Foundation for the Study of Diabetes. 2017-2020. Metabolic surgery as a treatment for diabetic kidney disease. €100,000 (Co-Principal Investigator)
  3. Health Research Board and National Institute of Health US-Ireland Partnership program 2016-2021, Food preferences after bariatric surgery. €2,500,000 (Co-Principal Investigator)
  4. Science Foundation Ireland – 2013-2018, Reversal of diabetic kidney disease. €902,000 (principal investigator)
  5. Swedish Vetenskapsrådet Grant 2016-2018. Mechanisms by which bariatric surgery changes diabetic kidney disease. SEK 2,100,00. (Principal Investigator)
  6. ALF Swedish Healthcare system – 2014-2017, The Potential of Octreotide as an Adjunct in Optimising Body Weight and Nutritional Status following Curative Surgery for Cancer of the Upper Gastrointestinal Tract. SEK 2,550,000 (principal investigator).
  7. Department of Health Clinician Scientist award – 2006-2011, Mechanisms of bariatric surgery. £922,000 (principal investigator)
  8. Wellcome Trust Clinic Research Fellowship – 2002-2005, Gut hormones and appetite. £387,000 (principal investigator)
  9. Diabetes Foundation – 2007-2013, Changes in the brain after bariatric surgery. £500,000 (co-applicant)
  10. Ethicon Surgery – 2009-2013, Patient benefit grant. £145,000  
  11. ONO pharmaceutical – 2010-2014, Mechanisms of glycaemic control after bariatric surgery. £272,000 (principal investigator)
  12. Moulton foundation – 2010-2013, Optimal care for patients before and after diabetes surgery. £166,000 (principal investigator)
  13. Newman Scholarship – 2013-2015, The Effect of GLP-1 on inflammation in Obesity. €95,000 (principal investigator)
  14. Johnson and Johnson – 2013-2018, Bariatric surgery as a treatment for diabetic kidney disease in Chile $2 000 000 (co-applicant)
  15. RO21 from NIH – 2012-2014, Food preference changes after bariatric surgery. $250 000 (co-applicant).

 

  1. Endocrine Society: First Authored Student Award for Endocrinology (2007)
  2. Association for Clinical Biochemsitry’s Professor’s prize for young investigators (2006)
  3. Association for the Study of Obesity Student Researcher award (2003)
  4. Nutrition Society Postgraduate competition co winner (2004)
  5. American Association of Clinical Chemistry travel grant (2001)
  6. Final year distinctions: Internal Medicine and Chemical Pathology.
  7. Anglo American Open Scholarship (1991 – 1996)
  8. University of Pretoria Achievement Bursary: (1991 & 1992)
  9. Five distinctions in Matriculation exams (equivalent to A levels)
  10. Elite track and field athlete: represented South Africa (1991-1995) ACADEMIC RELATED ACTIVITIES

 

Fellow of the Royal College of Pathologists

Fellow of the Royal College of Physicians (UK)

Fellow of the Royal College of Physicians of Ireland

Editor Metabolic Journal Watch 2008-2011

Regional Editor for Clinical Obesity 2010-present

Associate Editor of Journal of Clinical Pathology 2007-present

Associate Editor Surgery for Obesity and Related Diseases 2011-present

Vice Dean Faculty of Pathology, Royal College of Physicians of Ireland 2016-2018

 

MEMBERSHIP OF OTHER LEARNED SOCIETIES

 

  1. Chair World Obesity Federation Clinical Care Committee 2016
  2. Board member of Faculty of Pathology, Royal College of Physicians of Ireland 2014 –
  3. Director and Board member of the Irish Society for Clinical Nutrition and Metabolism (IrSPEN) 2014 -
  4. Chair of the Summer School programme for the International Association for Study of obesity 2013-
  5. Board member of the metabolic surgery committee of the international Federation for Surgery of Obesity 2012-
  6. Chair of Nutrition Clinical Practice Group of the Association of Clinical

Biochemistry 2009-2012

  1. Steering committee member International Diabetes Surgery Taskforce 2011-
  2. Steering committee member of UK LDL apheresis working group 2010-12
  3. Member International Diabetes Federation Taskforce bariatric surgery 2011
  4. Member of National Confidential Enquiry Patient Outcome and Death on bariatric surgery 2012
  5. Member Asian Diabetes Surgery Taskforce 2012
  6. Executive committee member of Association for Clinical Pathologists 2010-13

 

PhD STUDENTS

Dr Alexander Miras (2010-2013): MRC Clinical Research Fellowship £398650

Dr Samantha Scholtz (2008-2013): Wellcome Clinical Research Fellowship £413540

Dr Marco Bueter (2008-2011): The Deutsche Forschungsgemeinschaft (German Research Foundation) £187345

Mr Hutan Ashrafian (2008-2013): Wellcome Clinical Research Fellowship £376490

Mr Dimitri Pournaras (2009-2012): Royal College of Surgeons’ Fellowship £91200

Ms Ghalia Abdeen (2012-2016): Kingdom of Saudi Arabia Research Fellowship £75000

Ms Werd Al-Najim (2013-)

Dr Karl Neff (2012-2016)

Dr Jessie Elliott (2013-2017)

Mette Søndergaard Nielsen (2014-): Danish Diabetes Academy Fellow €191876

Meera Nair (2015-)

Dr Conor Murphy (2015-)

Dr Mohamed Mahmoud Abdelaal (2016-)

Andrew Garnell (2018-)

Natasha Kapoor (2016-)

Dr Piriyah Sinclair (2016-)

 

MPhil/MD STUDENTS

Dr Royce Vincent (2010-2012)

Dr Ling Ling Chuah (2012-2015)

Dr Aoife Canney (2014-2016)

Dr Michael Wilkinson (2018-)

 

MSc STUDENTS

Ms Sabrina Jackson (2013-2015)

Ms Alison Doody (2015-2016)

Ms Dora Gorman (2015-2016)

 

TEACHING COMMITMENTS

 

Head of subject for Pathology, UCD (2012-2015)

Head of Pathology Educational Research committee (2012-2015)

UCD Pathology curriculum review (2014-2015)

Establish USMLE module at UCD 2014

Endocrinology lectures for third year medical students 2001-2008

Nutrition lectures for third year medical students 2001-2010

Chemical Pathology lectures and tutorials for third year students 2000 – 2010

Teaching on Ealing and Hammersmith MRCP courses 2000-2010

EDUCATION

PRESENT APPOINTMENTS

Reader Metabolic Medicine, Imperial College London

Honorary Consultant Metabolic Medicine, King’s College Hospital, London Consultant

Professor of Experimental Pathology, University College Dublin

 

PREVIOUS APPOINTMENTS

Reader in Metabolic Medicine (10 Programmed activities)

 

1/1/10-31/7/12 Imperial College London

 

Senior Lecturer in Metabolic Medicine (10 Programmed activities)

 

1/2/06-31/12/2009 Imperial College London

 

Consultant Chemical Pathology (2 Programmed activities)

 

1/2/06-31/7/12 King’s College Hospital NHS Trust

 

Specialist Registrar &Wellcome Fellow: Metabolic Medicine and Chemical Pathology

 

2/2/00- 1/2/06 Charing Cross, Chelsea & Westminster and Hammersmith Hospitals Prof SR Bloom, Dr J Alaghband-Zadeh and Dr G Ball

 

Senior House Officer: Medicine

 

The Royal London, St. Bartholomew and Southend Hospital Rotation (30 months)

 

8/8/99 - 4/2/00 Endocrinology at St. Bartholomew Hospital Prof GM Besser (Professor of Medicine), Prof JP Monson, Prof                                                                                  AB Grossman, Dr. SL Chew, Dr PJ Jenkins 5/2/98 - 7/8/98

5/2/99 - 4/8/99 Chest and General Medicine at Southend Hospital

Dr. AG Davison (Consultant Chest Physician)

8/8/98 - 4/2/99 Medical Oncology at Southend Hospital

Dr. AC Robinson and A Lamont (Consultant Oncologists)

Nephrology and Neurology at Southend Hospital

Dr. MK Almond (Consultant Nephrologist)

Dr. DM Park (Consultant Neurologist)

 

Pre Registration House Officer

 

6/8/97 - 4/2/98  Stoke Mandeville Hospital (General Surgery)

Mr. J Tweedie (Consultant General Surgeon)

5/2/97 - 5/8/97  Doncaster Royal Infirmary (General Medicine and Cardiology)

Dr. MW Baig (Consultant Cardiologists)

Dr. G Payne (Consultant Cardiologist)

 

UNIVERSITY

University of Pretoria: MBChB (1991 - 1996)

 

SCHOOLS ATTENDED:

Laerskool Fleur (Primary School 1979 - 1985), Pretoria, South Africa

Hoërskool Waterkloof (Secondary School 1986 - 1990), Pretoria, South Africa

Extra Curricular Centre for highly gifted children (1983 - 1990) under the auspices of the Department of Education and the University of Pretoria

COMMUNICATIONS

INVITED, KEYNOTE or PLENARY LECTURES:

 

Obesity Week (Washington DC 2017)

International Diabetes Federation (Abu Dhabi 2017)

European Congress on Obesity (Lisbon 2017)

International Federation for Surgery of Obesity (London 2017)

European Association for Study of Diabetes (Lisbon 2017)

Obesity Week (New Orleans 2016)

International Federation for Surgery of Obesity (Rio de Janeiro 2016)

European Association for Study of Diabetes (Munich 2016)

Obesity Week (Los Angeles 2015)

International Diabetes Federation (Vancouver 2015)

International Federation for Surgery of Obesity (Vienna 2015)

European Association for Study of Diabetes (Stockholm 2015)

Obesity Week (Boston 2014)

European Association for Study of Diabetes (Vienna 2014)

International Federation for Clinical Chemistry (Pretoria 2014)

International Federation for Surgery of Obesity (Montreal 2014)

Digestive Disease Week (Chicago 2014),

Experimental Biology (San Diego 2014)

Keystone (Vancouver 2014)

International Federation for Surgery of Obesity (Istanbul 2013)

Obesity Week (Atlanta 2013)

American Diabetes Association (San Diego 2013)

Pan American Congress of diabetes surgery (Brasilia, 2013),

International Federation for Surgery of Obesity (New Delhi 2012)

Asian Metabolic Surgery Task Force (New Dehli 2012)

Physiology Society (Glasgow 2012),

International Federation for Surgery of Obesity (Barcelona 2012),

Digestive Disease Week (San Diego 2012),

Digestive Disorders Federation (Liverpool 2012),

Finnish obesity expert group’s annual meeting (Helsinki 2012),

Nordic bariatric surgery meeting (Oslo 2012),

Nature Medicine Young Investigator meeting (San Francesco 2011),

European Association for Study of Obesity (Munich 2011),

Pan American Congress of diabetes surgery (Porte Alegra 2011),

Innovation in Diabetes (Dublin 2011),

International Federation Surgery Obesity (Hamburg 2011)

Innovation in Diabetes (Dublin 2011)

World Congress on interventional diabetes therapies (New York 2011)

International Obesity Congress (Riyadh 2011)

Small animal research into mechanisms of bariatric surgery (Boston 2011)

International Federation for Surgery of Obesity (Lausanne 2010)

International Congress on Obesity Expert Group (Stockholm 2010)

Obesity Surgery Society Australia and New Zealand (Hobart 2010)

Annual International Symposium of the Merck-frosst / CIHR obesity research chair (Quebec 2010)

PanAmerican Congress of type 2 diabetes surgery (Sao Paolo 2010)

Annual Spanish bariatric surgery meeting (Malaga 2010)

European Obesity Academy (Stockholm 2010)

International Federation for Surgery of Obesity (Paris 2009)

Neurogastroenterology and Motility Meeting (Chicago 2009)

Physiology Society (Dublin 2009)

Rank Prize meeting (Grasmere 2009)

Greek Bariatric surgery Society (Athens 2009)

Norwegian Gastroenterology Society (Stavanger 2009)

Finnish Obesity Society (Kupio 2009)

European Congress on Obesity (Amsterdam, 2009)

International Federation for Surgery on Obesity (Buenos Aires 2008)

Society for Study of Ingestive Behaviour (Paris 2008)

Alberta Heritage Foundation for Medical Research Lecturer Award (Calgary 2008)

European Congress on Obesity (Geneva 2008)

European Association for Endoscopic Surgery (Stockholm 2008)

Association for Clinical Pathologists (Prague 2008)

Health of the Nation (London 2008)

FOCUS (Association for Clinical Biochemistry meeting, Birmingham 2008)

Zurich Vetinary University invited lecture (Zurich 2008)

9th Annual Symposium on obesity and diabetes (Quebec 2007)

FOCUS (Association for Clinical Biochemistry meeting, Manchester 2007)

Greek Obesity Society (Athens 2007)

International Congress on Obesity (Sydney 2006)

International Federation for Surgery of Obesity (Sydney 2006)

Association for Clinical Biochemistry (Brighton 2006)

Association for Clinical Biochemistry (Newport 2006)

Dutch Diabetes Association (Utrecht 2005)

International Federation for the Study of Obesity (Maastricht 2005)

 

INTERNATIONAL ADVISORY BOARDS

GI Dynamics (2013-)

NovoNordisk (2014-)

Herbalife (2013-)

Fractyl (2013-)

AnaBio (2015-)

Keyron (2018-)

Food Health Ireland (2016-18)

CLINICAL AUDIT

 

Presented at Audit meetings

 

  1. Thyroid Function Tests on acute medical admissions 1997
  2. The value of CKmb on acute admissions 1997
  3. Glucose: Laboratory analysis vs. near patient testing 1997
  4. The management of Thyroid nodules 1998
  1. Distribution of Cardiac Arrest Calls in a District General Hospital 1998
  2. Requests of INR during Warfarin loading 1998
  3. Effect of Atorvastatin on Lipid profiles in a Dialysis Unit (Essex Regional         Nephrology Audit meeting 25 May 1999)
  4. Cardiac Catheter laboratory and referrals to a tertiary centre (June 1999)
  5. Guidelines on CA 125 requests (Gynaecology audit meeting July 1999)
  6. Carcinoid Tumours - the Southend Hospital experience (1999)
  1. Dynamic function Test at Charing Cross Hospital 1/7/99 - 30/6/00
  1. Turnaround time for U&E December 2000
  2. Near patient testing device for Troponin T, December 2000
  3. Serum cortisol measurements before dynamic function testing July 2001
  1. Influence of Fenofibrate on HDL measurements August 2001

 

SPORT

 

ATHLETICS, represented South Africa at:

World Indoor Championships (Spain, 1995, 15th place)

Common Wealth Games (Canada, 1994, 4th place)

African Championships (South Africa, 1993, gold medal)

World Student Games (USA, 1993, 9th place)

South African University Team (1991, 1992, 1993, 1994)

South African Junior Champion and record holder (1991)

 

GENERAL INTERESTS

An interest in fine arts with a passion for travelling, good food and wine.  

PUBLICATIONS

 

Original publications

 

Werling M, Fändriks L, Olbers T, Mala T, Kristinsson J, Stenlöf K, Wallenius V, Docherty NG, le Roux CW. Biliopancreatic Diversion is associated with greater increases in energy expenditure than Roux-en-Y Gastric Bypass. PLoS One. 2018 Apr 4;13(4):e0194538. doi:  10.1371/journal.pone. 0194538. PMID: 29617391

 

Friedman AN, Wahed AS, Wang J, Courcoulas AP, Dakin G, Hinojosa MW, Kimmel PL, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, le Roux C, Spaniolas K, Steffen KJ, Thirlby R, Wolfe B. Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol. 2018 Apr;29(4):1289-1300. doi: 10.1681/ASN.2017060707. Epub 2018 Jan 15.

 

Shulman A, Peltonen M, Sjöström CD, Andersson-Assarsson JC, Taube M, Sjöholm K, le Roux CW, Carlsson LMS, Svensson PA. Incidence of end-stage renal disease following bariatric surgery in the Swedish Obese Subjects Study. Int J Obes (Lond). 2018 Feb 26. doi: 10.1038/s41366-018-0045-x. PMID: 29568103

 

Mistry P, Currie V, Super P, le Roux CW, Tahrani AA, Singhal R. Changes in glycaemic control, blood pressure and lipids 5 years following laparoscopic adjustable gastric banding combined with medical care in patients with type 2 diabetes: a longitudinal analysis. Clin Obes. 2018 Mar 4. doi: 10.1111/cob.12244. PMID: 29504275

 

Wallenius V, Dirinck E, Fändriks L, Maleckas A, le Roux CW, Thorell A. Glycemic Control after Sleeve Gastrectomy and Roux-En-Y Gastric Bypass in Obese Subjects with Type 2 Diabetes Mellitus. Obes Surg. 2017 Dec 20. doi: 10.1007/s11695-017-3061-3. [Epub ahead of print] PMID: 29264780

 

Abdeen GN, Miras AD, Alqhatani AR, le Roux CW. Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents. Obes Surg. 2017 Dec 2. doi: 10.1007/s11695-017-2999-5. [Epub ahead of print] PMID: 29198070

 

Ooi GJ, Earnest A, Doyle L, Laurie C, Wentworth JM, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. Detailed Description of Change in Serum Cholesterol Profile with Incremental Weight Loss After Restrictive Bariatric Surgery. Obes Surg. 2017 Nov 21. doi: 10.1007/s11695-017-3015-9. [Epub ahead of print] PMID: 29159554

 

Doody A, Jackson S, Elliott JA, Canavan RJ, Godson C, Slattery D, Twomey PJ, McKenna MJ, le Roux CW, Docherty NG. Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes. J Diabetes Complications. 2018 Jan;32(1):95-99. doi: 10.1016/j.jdiacomp.2017.09.007. Epub 2017 Sep 18. PMID: 29122448

 

Tang T, Abbott S, le Roux CW, Wilson V, Singhal R, Bellary S, Tahrani A. Preoperative Weight Loss With GLP-1 Receptor Agonist Treatment Predicts Greater Weight Loss Achieved by the Combination of Medical Weight Management And Bariatric Surgery In Patients With Type 2 Diabetes: A Longitudinal Analysis. Diabetes Obes Metab. 2017 Oct 20. doi: 10.1111/dom.13131. [Epub ahead of print] PMID: 29053203

 

Cohen R, le Roux CW, Junqueira S, Ribeiro RA, Luque A. Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity: a Systematic Review and Meta-analysis. Obes Surg. 2017 Aug 7. doi: 10.1007/s11695-017-2869-1. [Epub ahead of print] PMID: 28785975

 

Risstad H, Kristinsson JA, Fagerland MW, le Roux CW, Birkeland KI, Gulseth HL, Thorsby PM, Vincent RP, Engström M, Olbers T, Mala T. Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial. Surg Obes Relat Dis. 2017 Sep;13(9):1544-1553. doi: 10.1016/j.soard.2017.05.024. Epub 2017 May 25. PMID: 28756050

 

Docherty NG, Fändriks L, le Roux CW, Hallersund P, Werling M. Urinary sodium excretion after gastric bypass surgery. Surg Obes Relat Dis. 2017 Sep;13(9):1506-1514. doi: 10.1016/j.soard.2017.04.002. Epub 2017 Apr 8. PMID: 28571926

 

Arora T, Seyfried F, Docherty NG, Tremaroli V, le Roux CW, Perkins R, Bäckhed F. Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass. ISME J. 2017 Sep;11(9):2035-2046. doi: 10.1038/ismej.2017.70. Epub 2017 May 19. PMID: 28524868

 

Cohen RV, Luque A, Junqueira S, Ribeiro RA, Le Roux CW. What is the impact on the healthcare system if access to bariatric surgery is delayed? Surg Obes Relat Dis. 2017 Sep;13(9):1619-1627. doi: 10.1016/j.soard.2017.03.025. Epub 2017 Mar 31. PMID: 28499887

Similar articles

 

Miras AD, le Roux CW. Metabolic Surgery in a Pill. Cell Metab. 2017 May 2;25(5):985-987. doi: 10.1016/j.cmet.2017.04.028. PMID: 28467941

Laurenius A, Werling M, le Roux CW, Fändriks L, Olbers T. Dumping symptoms is triggered by fat as well as carbohydrates in patients operated with Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017 Jul;13(7):1159-1164. doi: 10.1016/j.soard.2017.02.020. Epub 2017 Mar 1. PMID: 28433465

 

Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, le Roux CW, Sjödin A, Schmidt JB. Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Does Not Affect Food Preferences When Assessed by an Ad libitum Buffet Meal. Obes Surg. 2017 Apr 14. doi: 10.1007/s11695-017-2678-6. [Epub ahead of print] PMID: 28411313

 

Miras AD, Herring R, Vusirikala A, Shojaee-Moradi F, Jackson NC, Chandaria S, Jackson SN, Goldstone AP, Hakim N, Patel AG, Umpleby AM, Le Roux CW. Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans. Obes Sci Pract. 2017 Mar;3(1):95-98. doi: 10.1002/osp4.76. Epub 2016 Dec 29. PMID: 28392935

 

Hyde KM, Blonde GD, le Roux CW, Spector AC. Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection. Physiol Behav. 2017 Aug 1;177:4-12. doi: 10.1016/j.physbeh.2017.03.045. Epub 2017 Mar 30. PMID: 28366815

 

Ooi GJ, Doyle L, Tie T, Wentworth JM, Laurie C, Earnest A, Cowley MA, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components. Int J Obes (Lond). 2017 Jun;41(6):902-908. doi: 10.1038/ijo.2017.59. Epub 2017 Mar 6. PMID: 28262677

 

O'Neill KN, Finucane FM, le Roux CW, Fitzgerald AP, Kearney PM. Unmet need for bariatric surgery. Surg Obes Relat Dis. 2017 Jun;13(6):1052-1056. doi: 10.1016/j.soard.2016.12.015. Epub 2016 Dec 23. PMID: 28256395

 

le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DC, Van Gaal L, Ortiz RV, Wilding JP, Skjøth TV, Manning LS, Pi-Sunyer X; 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. SCALE Obesity.; Prediabetes NN8022-1839 Study Group. Lancet. 2017 Feb 22. pii: S0140-6736(17)30069-7. doi: 10.1016/S0140-6736(17)30069-7. [Epub ahead of print]. PMID: 28237263

Pournaras DJ, Hardwick RH, le Roux CW. Gastrointestinal surgery for obesity and cancer: 2 sides of the same coin. Surg Obes Relat Dis. 2016 Dec 23. pii: S1550-7289(16)30878-4. doi: 10.1016/j.soard.2016.12.014. [Epub ahead of print] PMID: 28161354

 

Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S. Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels. Sci Rep. 2016 Oct 20;6:35727. doi: 10.1038/srep35727.

PMID: 27760995

 

Melvin A, le Roux CW, Docherty NG. Which Organ is Responsible for the Pathogenesis of Obesity? Ir Med J. 2016 Apr 11;109(4):395. PMID: 27685489

 

Neff KJ, Elliott JA, Corteville C, Abegg K, Boza C, Lutz TA, Docherty NG, le Roux CW. Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat. Surg Obes Relat Dis. 2016 Aug 18. PMID: 27665150

 

Hunt KF, Dunn JT, le Roux CW, Reed LJ, Marsden PK, Patel AG, Amiel SA. Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study. Diabetes Care. 2016 Oct;39(10):1787-95. doi: 10.2337/dc15-2721. PMID: 27660120

 

Elliott JA, Docherty NG, Eckhardt HG, Doyle SL, Guinan EM, Ravi N, Reynolds JV, le Roux CW. Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study. Ann Surg. 2016 Jul 22. PMID: 27455150

 

Neff KJ, Baud G, Raverdy V, Caiazzo R, Verkindt H, Noel C, le Roux CW, Pattou F. Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study. Obes Surg. 2016 Sep 14. PMID: 27628054

 

Maghsoodi N, Alaghband-Zadeh J, Cross G, Werling M, Fandriks L, Docherty NG, Olbers T, Dew T, Sherwood R, Vincent RP, le Roux CW. Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB). Ann Clin Biochem. 2016 Aug 23. pii: 0004563216667964. PMID: 27555664

 

Pournaras DJ, Nygren J, Hagström-Toft E, Arner P, le Roux CW, Thorell A. Improved glucose metabolism after gastric bypass: evolution of the paradigm. Surg Obes Relat Dis. 2016 Mar 23. PMID: 27387696

 

Mossberg KE, Pournaras DJ, Welbourn R, le Roux CW, Brogren H. Differential response of plasma plasminogen activator inhibitor 1 after weight loss surgery in patients with or without type 2 diabetes. Surg Obes Relat Dis. 2016 Mar 14. PMID: 27387691

 

Welbourn R, le Roux CW, Owen-Smith A, Wordsworth S, Blazeby JM. Why the NHS should do more bariatric surgery; how much should we do? BMJ. 2016 May 11;353:i1472. doi: 10.1136/bmj.i1472. PMID: 27169605

 

Del Genio G, Gagner M, Limongelli P, Tolone S, Pournaras D, le Roux CW, Brusciano L, Licia Mozzillo A, Del Genio F, Docimo L. Remission of type 2 diabetes in patients undergoing biliointestinal bypass for morbid obesity: a new surgical treatment. Surg Obes Relat Dis. 2015 Dec 7. pii: S1550-7289(15)01093-X. doi: 10.1016/j.soard.2015.12.003. [Epub ahead of print] PMID: 27150339

 

Elliott JA, le Roux CW. Type 2 diabetes with BMI<30 kg/m2: Can we predict success of metabolic surgery? Surg Obes Relat Dis. 2016 Mar 16. pii: S1550-7289(16)00102-7. doi: 10.1016/j.soard.2016.03.012. PMID: 27130137

 

Neff KJ, le Roux CW. Bariatric surgery: traversing the CROSSROADS into mainstream diabetes care. Diabetologia. 2016 May;59(5):942-4. doi: 10.1007/s00125-016-3928-1. Epub 2016 Mar 16. No abstract available. PMID: 26983923

 

Qvigstad E, Gulseth HL, Risstad H, le Roux CW, Berg TJ, Mala T, Kristinsson JA. A novel technique of Roux-en-Y gastric bypass reversal for postprandial hyperinsulinemic hypoglycaemia: A case report. Int J Surg Case Rep. 2016 Feb 27;21:91-94. doi: 10.1016/j.ijscr.2016.02.033. PMID: 26957187

 

Dutia R, Embrey M, O'Brien S, Haeusler RA, Agénor KK, Homel P, McGinty J, Vincent RP, Alaghband-Zadeh J, Staels B, le Roux CW, Yu J, Laferrère B. Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes. Int J Obes (Lond). 2016 Mar;40(3):554. doi: 10.1038/ijo.2015.250. PMID: 26952775

 

Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC. Roux-en-Y Gastric Bypass in Rats Progressively Decreases the Proportion of Fat Calories Selected from a Palatable Cafeteria Diet. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 10:ajpregu.00444.2015. doi: 10.1152/ajpregu.00444.2015. PMID: 26864811

 

Wilding JP, Overgaard RV, Jacobsen LV, Jensen CB, le Roux CW. Exposure-response analyses of liraglutide 3.0 mg for weight management. Diabetes Obes Metab. 2016 Feb 2. doi: 10.1111/dom.12639. [Epub ahead of print] PMID: 26833744

 

Jung J, Ha TK, Lee J, Lho Y, Nam M, Lee D, le Roux CW, Ryu DH, Ha E, Hwang GS. Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Am J Physiol Endocrinol Metab. 2016 Jan 19:ajpendo.00260.2015. doi: 10.1152/ajpendo.00260.2015. [Epub ahead of print] PMID: 26786776

 

Coluzzi I, Raparelli L, Guarnacci L, Paone E, Del Genio G, le Roux CW, Silecchia G. Food Intake and Changes in Eating Behavior After Laparoscopic Sleeve Gastrectomy. Obes Surg. 2016 Jan 7. [Epub ahead of print] PMID: 26744284

 

Welbourn R, Dixon J, Barth JH, Finer N, Hughes CA, le Roux CW, Wass J; Guidance Development Group. NICE-Accredited Commissioning Guidance for Weight Assessment and Management Clinics: a Model for a Specialist Multidisciplinary Team Approach for People with Severe Obesity. Obes Surg. 2016 Jan 6. [Epub ahead of print] PMID: 26738895

 

van Avesaat M, Troost FJ, Westerterp-Plantenga MS, Helyes Z, le Roux CW, Dekker J, Masclee AA, Keszthelyi D. Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones. Am J Clin Nutr.

2016 Feb;103(2):305-13. doi: 10.3945/ajcn.115.123414. Epub 2015 Dec 30. PMID: 26718419

 

le Roux CW, Engström M, Björnfot N, Fändriks L, Docherty NG. Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction Following Bariatric Surgery. Obes Surg. 2015 Dec 16. [Epub ahead of print] PMID: 26677057

 

Spector AC, le Roux CW, Munger SD, Travers SP, Sclafani A, Mennella JA. Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health. JPEN J Parenter Enteral Nutr. 2015 Nov 23. pii: 0148607115617438. [Epub ahead of print] PMID: 26598504

 

Elliott JA, Jackson S, King S, McHugh R, Docherty NG, Reynolds JV, le Roux CW. Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction. Ann Surg. 2015 Nov;262(5):824-30. doi: 10.1097/SLA.0000000000001465. PMID: 26583672

 

Goldstone AP, Miras AD, Scholtz S, Jackson S, Neff KJ, Pénicaud L, Geoghegan J, Chhina N, Durighel G, Bell JD, Meillon S, le Roux CW. Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity. J Clin Endocrinol Metab. 2015 Nov 18:jc20152665. [Epub ahead of print] PMID: 26580235

 

de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Bouvy ND, Greve JW. Impact of Duodenal-Jejunal Exclusion on Satiety Hormones. Obes Surg. 2015 Oct 7. [Epub ahead of print] PMID: 26446491

 

Pournaras DJ, le Roux CW. Type 2 diabetes: multimodal treatment of a complex disease. Lancet. 2015 Sep 5;386(9997):936-7. doi: 10.1016/S0140-6736(15)00132-4.PMID: 26369451

 

Belgaumkar AP, Vincent RP, Carswell KA, Hughes RD, Alaghband-Zadeh J, Mitry RR, le Roux CW, Patel AG. Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease. Obes Surg. 2015 Sep 4. [Epub ahead of print] PMID: 26337697

 

Mathes CM, Bohnenkamp RA, le Roux CW, Spector AC. Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R864-74. doi: 10.1152/ajpregu.00029.2015. Epub 2015 Aug 19. PMID: 26290100

 

Maguire PJ, Power KA, O'Higgins AC, Jackson S, Harley R, le Roux CW, Turner MJ. Maternal C-reactive protein in early pregnancy. Eur J Obstet Gynecol Reprod Biol. 2015 Oct;193:79-82. doi: 10.1016/j.ejogrb.2015.07.005. Epub 2015 Jul 21. PMID: 26254855

 

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F. Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation. Cell Metab. 2015 Aug 4;22(2):228-38. doi: 10.1016/j.cmet.2015.07.009. PMID: 26244932

 

Boxwell AJ, Chen Z, Mathes CM, Spector AC, le Roux CW, Travers SP, Travers JB. Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus. Physiol Behav. 2015 Dec 1;152(Pt B):329-39. doi: 10.1016/j.physbeh.2015.07.025. Epub 2015 Jul 26. Review. PMID: 26216080

 

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. New England Journal Medicine. 2015 Jul 2;373(1):11-22. doi: 10.1056/NEJMoa1411892. PMID: 26132939

 

Alsters SI, Goldstone AP, Buxton JL, Zekavati A, Sosinsky A, Yiorkas AM, Holder S, Klaber RE, Bridges N, van Haelst MM, le Roux CW, Walley AJ, Walters RG, Mueller M, Blakemore AI. Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism. PLoS One. 2015 Jun 29;10(6):e0131417. doi: 10.1371/journal.pone.0131417. eCollection 2015. PMID: 26120850

 

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW. Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake. PLoS One. 2015 Jun 22;10(6):e0129784. doi: 10.1371/journal.pone.0129784. eCollection 2015. PMID: 26098889

 

Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M, Bäckhed F. Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. PLoS One. 2015 May 6;10(5):e0126401. doi: 10.1371/journal.pone.0126401. eCollection 2015. PMID: 25946120

 

Miras AD, Chuah LL, Khalil N, Nicotra A, Vusirikala A, Baqai N, Graham C, Ravindra S, Lascaratos G, Oliver N, le Roux CW. Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a case-control study. Diabetologia. 2015 Jul;58(7):1443-7. doi: 10.1007/s00125-015-3595-7. Epub 2015 Apr 18.

 

Chuah LL, Miras AD, Papamargaritis D, Jackson SN, Olbers T, le Roux CW. Impact of perioperative management of glycemia in severely obese diabetic patients undergoing gastric bypass surgery. Surg Obes Relat Dis. 2015 May-Jun;11(3):578-84. doi: 10.1016/j.soard.2014.11.004. Epub 2014 Nov 13. PMID: 25863535

 

Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL. Aspartame sensitivity? A double blind randomised crossover study. PLoS One. 2015 Mar 18;10(3):e0116212. doi: 10.1371/journal.pone.0116212. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126039. PMID: 25786106

 

Wu Q, Li JV, Seyfried F, le Roux CW, Ashrafian H, Athanasiou T, Fenske W, Darzi A, Nicholson JK, Holmes E, Gooderham NJ. Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery. Int J Obes (Lond). 2015 Jul;39(7):1126-34. doi: 10.1038/ijo.2015.33. Epub 2015 Mar 18. PMID: 25783038

 

Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, Lutz TA, le Roux CW, Spector AC. Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiol Behav. 2015 Apr 1;142:179-88. doi: 10.1016/j.physbeh.2015.02.004. Epub 2015 Feb 3. PMID: 25660341

 

Risstad H, Søvik TT, Engström M, Aasheim ET, Fagerland MW, Olsén MF, Kristinsson JA, le Roux CW, Bøhmer T, Birkeland KI, Mala T, Olbers T. Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 2015 Apr;150(4):352-61. doi: 10.1001/jamasurg.2014.3579. PMID: 25650964

 

Abegg K, Corteville C, Docherty NG, Boza C, Lutz TA, Muñoz R, le Roux CW. Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol. 2015 Feb 15;308(4):R321-9. doi: 10.1152/ajpregu.00331.2014. PMID: 25540099

 

Sam AH, Sleeth ML, Thomas EL, Ismail NA, Mat Daud N, Chambers E, Shojaee-Moradie F, Umpleby M, Goldstone AP, le Roux CW, Bech P, Busbridge M, Laurie R, Cuthbertson DJ, Buckley A, Ghatei MA, Bloom SR, Frost GS, Bell JD, Murphy KG. Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. J Clin Endocrinol Metab. 2015 Mar;100(3):1048-52. doi: 10.1210/jc.2014-3450.

 

Angelopoulos T, Kokkinos A, Liaskos C, Tentolouris N, Alexiadou K, Miras AD, Mourouzis I, Perrea D, Pantos C, Katsilambros N, Bloom SR, le Roux CW. The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2014 Jul 2;2(1):e000013. eCollection 2014.

 

Kim JY, Ha TK, le Roux CW. Metabolic effects of gastrectomy with or without omentectomy in gastric cancer. Hepatogastroenterology. 2014 Sep;61(134):1830-4.

 

Werling M, Fändriks L, Royce VP, Cross GF, le Roux CW, Olbers T. Preoperative assessment of gut hormones does not correlate to weight loss after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2014 Sep-Oct;10(5):822-8. doi: 10.1016/j.soard.2014.04.018. Epub 2014 Apr 29.

 

Miras AD, Seyfried F, Phinikaridou A, Andia ME, Christakis I, Spector AC, Botnar RM, le Roux CW. Rats fed diets with different energy contribution from fat do not differ in adiposity. Obes Facts. 2014;7(5):302-10. doi: 10.1159/000368622. Epub 2014 Oct 1.

 

Papamargaritis D, Aasheim ET, Sampson B, le Roux CW. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2014 Sep 16. pii: S0946-672X(14)00174-6.

 

Elias E, Casselbrant A, Werling M, Abegg K, Vincent RP, Alaghband-Zadeh J, Olbers T, le Roux CW, Fändriks L, Wallenius V. Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric surgery. Br J Surg. 2014 Nov;101(12):1566-75. doi: 10.1002/bjs.9626. Epub 2014 Sep 10.

 

Laurenius A, Werling M, Le Roux CW, Fändriks L, Olbers T. More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2014 Apr 18. pii: S1550-7289(14)00156-7. doi: 10.1016/j.soard.2014.04.007. [Epub ahead of print]

 

Miras AD, Al-Najim W, Jackson SN, McGirr J, Cotter L, Tharakan G, Vusirikala A, le Roux CW, Prechtl CG, Scholtz S. Psychological characteristics, eating behavior, and quality of life assessment of obese patients undergoing weight loss interventions. Scand J Surg. 2014 Jul 22. pii: 1457496914543977.

 

Bhutta HY, Deelman TE, le Roux CW, Ashley SW, Rhoads DB, Tavakkoli A. Intestinal sweet-sensing pathways and metabolic changes after Roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G588-93.

 

Seyfried F, Bueter M, Spliethoff K, Miras AD, Abegg K, Lutz TA, le Roux CW. Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats. Obes Surg. 2014 Jun 15.

 

Bächler T, Schiesser M, Lutz TA, le Roux CW, Bueter M. Where to begin and where to end? Preoperative assessment for patients undergoing metabolic surgery. Dig Surg. 2014;31(1):25-32

 

Taylor DR, Alaghband-Zadeh J, Cross GF, Omar S, le Roux CW, Vincent RP. Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2. PLoS One. 2014 Apr 15;9(4):e93540.

 

Goyale A, Ashley SL, Taylor DR, Elnenaei MO, Alaghband-Zadeh J, Sherwood RA, le Roux CW, Vincent RP. Predicting refeeding hypophosphataemia: Insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice. Ann Clin Biochem. 2014 Mar 7.

 

Neff KJ, Prener C, Chuah LL, O'Donnell K, Godsland IF, Miras AD, le Roux CW. A holistic assessment of bariatric surgical outcomes in a Northern Irish cohort. Ir Med J. 2014 Jan;107(1):24-6.

 

Lyons T, Neff KJ, Benn J, Chuah LL, le Roux CW, Gilchrist M. Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery. Surg Obes Relat Dis. 2014 Mar-Apr;10(2):291-7.

 

Carswell KA, Vincent RP, Belgaumkar AP, Sherwood RA, Amiel SA, Patel AG, le Roux CW. The effect of bariatric surgery on intestinal absorption and transit time. Obes Surg. 2014 May;24(5):796-805.

 

Neff KJ, Chuah LL, Aasheim ET, Jackson S, Dubb SS, Radhakrishnan ST, Sood AS, Olbers T, Godsland IF, Miras AD, le Roux CW. Beyond weight loss: evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band. Obes Surg. 2014 May;24(5):684-91

 

Salinari S, le Roux CW, Bertuzzi A, Rubino F, Mingrone G. Duodenal-jejunal bypass and jejunectomy improve insulin sensitivity in Goto-Kakizaki diabetic rats without changes in incretins or insulin secretion. Diabetes. 2014 Mar;63(3):1069-78.

 

Tako AA, Kotiadis K, Vasilakis C, Miras A, le Roux CW. Improving patient waiting times: a simulation study of an obesity care service. BMJ Qual Saf. 2014 May;23(5):373-81

 

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP. Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut. 2014 Jun;63(6):891-902.

 

Miras AD, Risstad H, Baqai N, Law S, Søvik TT, Mala T, Olbers T, Kristinsson JA, le Roux CW. Application of the International Diabetes Federation and American Diabetes Association criteria in the assessment of metabolic control after bariatric surgery. Diabetes Obes Metab. 2014 Jan;16(1):86-9.

 

Goyale A, Ashley SL, Taylor DR, Elnenaei MO, Alaghband-Zadeh J, Sherwood RA, le Roux CW, Vincent RP. Predicting refeeding hypophosphataemia: Insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice. Ann Clin Biochem. 2014 Mar 7. [Epub ahead of print]

 

Werling M, Vincent RP, Cross GF, Marschall HU, Fändriks L, Lönroth H, Taylor DR, Alaghband-Zadeh J, Olbers T, le Roux CW. Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery. Scand J Gastroenterol. 2013 Nov;48(11):1257-64. doi: 10.3109/00365521.2013.833647. Epub 2013 Sep 18.

 

Cohen R, le Roux CW, Papamargaritis D, Salles JE, Petry T, Correa JL, Pournaras DJ, Galvao Neto M, Martins B, Sakai P, Schiavon CA, Sorli C. Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes. Diabet Med. 2013 Jun 26. doi: 10.1111/dme.12268. [Epub ahead of print]

 

Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. Hepcidin levels in diabetes mellitus and polycystic ovary syndrome. Diabet Med. 2013 Jun 24. doi: 10.1111/dme.12262.

 

Pournaras DJ, le Roux CW. Are bile acids the new gut hormones? Lessons from weight loss surgery models. Endocrinology. 2013 Jul;154(7):2255-6. doi: 10.1210/en.2013-1383. No abstract available.

 

Vincent RP, Omar S, Ghozlan S, Taylor DR, Cross G, Sherwood RA, Fandriks L, Olbers T, Werling M, Alaghband-Zadeh J, le Roux CW. Higher circulating bile acid concentrations in obese patients with type 2 diabetes. Ann Clin Biochem. 2013 Jul;50(Pt 4):360-4. doi: 10.1177/0004563212473450. Epub 2013 Jun 14.

 

Osto M, Abegg K, Bueter M, le Roux CW, Cani PD, Lutz TA. Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine. Physiol Behav. 2013 Jul 2;119:92-6. doi: 10.1016/j.physbeh.2013.06.008. Epub 2013 Jun 14.

 

Seyfried F, Miras AD, Bueter M, Prechtl CG, Spector AC, le Roux CW. Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats. Surg Endosc. 2013 Nov;27(11):4192-201. doi: 10.1007/s00464-013-3020-6. Epub 2013 May 30.

 

Werling M, Olbers T, Fändriks L, Bueter M, Lönroth H, Stenlöf K, le Roux CW. Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty. PLoS One. 2013;8(4):e60280. doi: 10.1371/journal.pone.0060280. Epub 2013 Apr 3.

 

de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Schaper NC, Bouvy ND, Greve JW. Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes. Obes Surg. 2013 Sep;23(9):1354-60. doi: 10.1007/s11695-013-0921-3.

 

Fenske WK, Dubb S, Bueter M, Seyfried F, Patel K, Tam FW, Frankel AH, le Roux CW. Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study. Surg Obes Relat Dis. 2013 Jul-Aug;9(4):559-68. doi: 10.1016/j.soard.2012.03.009. Epub 2012 Apr 10.

 

Iesari S, le Roux CW, De Gaetano A, Manco M, Nanni G, Mingrone G. Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric surgery. J Clin Endocrinol Metab. 2013 Feb;98(2):E321-7.

Seyfried F, Li JV, Miras AD, Cluny NL, Lannoo M, Fenske WK, Sharkey KA, Nicholson JK, le Roux CW, Holmes E. Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice. J Proteome Res. 2013 Mar 1;12(3):1245-53.

Papamargaritis D, le Roux CW, Sioka E, Koukoulis G, Tzovaras G, Zacharoulis D. Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2013 Mar-Apr;9(2):192-201.

Werling M, Fändriks L, Björklund P, Maleckas A, Brandberg J, Lönroth H, le Roux CW, Olbers T. Long-term results of a randomized clinical trial comparing Roux-en-Y gastric bypass with vertical banded gastroplasty. Br J Surg. 2013 Jan;100(2):222-30.

Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, Spector AC, le Roux CW. Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task. Am J Clin Nutr. 2012 Sep;96(3):467-73

Miras AD, Chuah LL, Lascaratos G, Faruq S, Mohite AA, Shah PR, Gill M, Jackson SN, Johnston DG, Olbers T, le Roux CW. Bariatric surgery does not exacerbate and may be beneficial for the microvascular complications of type 2 diabetes. Diabetes Care. 2012 Dec;35(12):e81-82.

Pournaras DJ, Glicksman C, Vincent RP, Kuganolipava S, Alaghband-Zadeh J, Mahon D, Bekker JH, Ghatei MA, Bloom SR, Walters JR, Welbourn R, le Roux CW. The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control. Endocrinology. 2012 Aug;153(8):3613-9.

Mul JD, Begg DP, Alsters SI, van Haaften G, Duran KJ, D'Alessio DA, le Roux CW, Woods SC, Sandoval DA, Blakemore AI, Cuppen E, van Haelst MM, Seeley RJ. Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. Am J Physiol Endocrinol Metab. 2012 Apr 24. doi: 10.1152/ajpendo.00159.2012

Patle R, Dubb S, Alaghband-Zadeh J, Sherwood RA, Tam F, Frankel A, Moniz C, Bueter M, Vincent RP, le Roux CW. Improved blood pressure, nitric oxide and asymmetric dimethylarginine are independent after bariatric surgery. Ann Clin Biochem. 2012 Nov;49(Pt 6):589-94

Roberts RE, Zhao M, Whitelaw BC, Ramage J, Diaz-Cano S, le Roux CW, Quaglia A, Huang GC, Aylwin SJ. GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia. J Clin Endocrinol Metab. 2012 Sep;97(9):3039-45

Hankir M, Bueter M, Gsell W, Seyfried F, Khalil M, Smith KL, Bloom SR, Bell JD, le Roux CW. Increased energy expenditure in gastric bypass rats is not caused by activated brown adipose tissue. Obes Facts. 2012;5(3):349-58

Bueter M, Abegg K, Seyfried F, Lutz TA, le Roux CW. Roux-en-Y gastric bypass operation in rats. J Vis Exp. 2012 Jun 11;(64):e3940.

Vincent RP, Omar S, Elnenaei MO, Goo CH, Salota R, Wu P, Delaney HL, le Roux CW. Adherence to the national institute of clinical excellence guidance on parenteral nutrition screening is not enough to improve outcomes. Clin Nutr. 2012 Jun 9.

Roberts RE, Zhao M, Whitelaw BC, Ramage J, Diaz-Cano S, le Roux CW, Quaglia A, Huang GC, Aylwin SJ. GLP-1 and Glucagon Secretion from a Pancreatic Neuroendocrine Tumor Causing Diabetes and Hyperinsulinemic Hypoglycemia. J Clin Endocrinol Metab. 2012 Jul 6.

Seyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer CT, le Roux CW. Roux-en-Y Gastric Bypass in Mice-Surgical Technique and Characterisation. Obes Surg. 2012 Jul;22(7):1117-25

Fenske WK, Dubb S, Bueter M, Seyfried F, Patel K, Tam FW, Frankel AH, le Roux CW. Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study. Surg Obes Relat Dis. 2012 Apr 10.

Pournaras DJ, Aasheim ET, Bueter M, Ahmed A, Welbourn R, Olbers T, le Roux CW. Effect of bypassing proximal gut on gut hormones involved with glycemic control and weight loss. Surg Obes Relat Dis. 2012 Mar 3.

Ratner C, Ettrup A, Bueter M, Haahr ME, Compan V, le Roux CW, Levin B, Hansen HH, Knudsen GM. Cerebral Markers of the Serotonergic System in Rat Models of Obesity and After Roux-en-Y Gastric Bypass. Obesity (Silver Spring). 2012 Mar 26. doi: 10.1038/oby.2012.75.

Pournaras DJ, Aasheim ET, Søvik TT, Andrews R, Mahon D, Welbourn R, Olbers T, le Roux CW. Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders. Br J Surg. 2012 Jan;99(1):100-3.

Fenske WK, Pournaras DJ, Aasheim ET, Miras AD, Scopinaro N, Scholtz S, le Roux CW. Can a Protocol for Glycaemic Control Improve Type 2 Diabetes Outcomes After Gastric Bypass? Obes Surg. 2012 Jan;22(1):90-6.

Mathes CM, Bueter M, Smith KR, Lutz TA, le Roux CW, Spector AC. Roux-en-Y Gastric Bypass in Rats Increases Sucrose Taste-Related Motivated Behavior Independent of Pharmacological GLP-1-Receptor Modulation. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15;302(6):R751-67.

Li JV, Reshat R, Wu Q, Ashrafian H, Bueter M, le Roux CW, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes E, Gooderham NJ. Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents. Front Microbiol. 2011;2:183.

Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CW. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiol Behav. 2011 Oct 24;104(5):709-21.

Atogo-Asse FE, Vincent RP, Hughes SA, Auzinger G, le Roux CW, Wendon J, Bernal W. High density lipoprotein in patients with liver failure; relation to sepsis, adrenal function and outcome of illness. Liver Int. 2012 Jan;32(1):128-36.

le Roux CW, Bueter M, Theis N, Werling M, Ashrafian H, Löwenstein C, Athanasiou T, Bloom SR, Spector AC, Olbers T, Lutz TA. Gastric bypass reduces fat intake and preference. Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1057-66.

Fenske WK, Bueter M,  Miras AD, Ghatei MA, Bloom SR, le Roux CW. Exogenous Peptide YY 3–36 and Exendin-4 further decrease food intake, whilst octreotide increases food intake in rats after Roux-en-Y Gastric Bypass. Int J Obes 2012 Mar;36(3):379-84.

Elnenaei MO, Alaghband-Zadeh J, Sherwood R, Awara MA, Moniz C, le Roux CW. Leptin and insulin growth factor 1: diagnostic markers of the refeeding syndrome and mortality. Br J Nutr. 2011 May 4:1-7

 

Parker HE, Wallis K, le Roux CW, Wong KY, Reimann F, Gribble FM. Molecular mechanisms underlying bile acid stimulated glucagon-like peptide-1 secretion. Br J Pharmacol. 2012 Jan;165(2):414-23.

 

Roberts RE, Glicksman C, Alaghband-Zadeh J, Sherwood RA, Akuji N, le Roux CW. The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin. Clin Endocrinol (Oxf). 2011 Jan;74(1):67-72

 

Dixon AF, le Roux CW, Ghatei MA, Bloom SR, McGee TL, Dixon JB. Pancreatic Polypeptide Meal Response May Predict Gastric Band-Induced Weight Loss. Obes Surg. 2011 Dec;21(12):1906-13

 

Hall JI, Vora N, Langworthy R, Stock S, Momin A, Sherwood RA, le Roux CW, Alaghband-Zadeh J. Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. Ann Clin Biochem. 2011 Jul;48(Pt 4):327-31.

 

Beckman LM, Beckman TR, Sibley SD, Thomas W, Ikramuddin S, Kellogg TA, Ghatei MA, Bloom SR, le Roux CW, Earthman CP. Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery. J Parenter Enteral Nutr. 2011 Mar;35(2):169-80.

 

Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW, Bloom SR, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes E. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 2011 Sep;60(9):1214-23.

 

Pournaras DJ, Osborne A, Hawkins SC, Mahon D, Ewings P, Ghatei MA,  Bloom SR, Welbourn R, le Roux CW. Mechanism of rapid remission for type 2 diabetes after gastric bypass surgery.  A prospective cohort study. Ann Surg 2010 Dec;252(6):966-71.

 

Bueter M, Dubb SS, Gill A, Joannou L, Ahmed A, Frankel AH, Tam FW, le Roux CW. Renal cytokines improve early after bariatric surgery. Br J Surg. 2010 Dec;97(12):1838-44.

 

le Roux CW, Borg C, Wallis K, Vincent RP, Bueter M, Ghatei MA, Bloom, SR, Patel AG, Aylwin SJB. Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation. Ann Surg 2010 Jul;252(1):50-6.

 

Bueter M, Löwenstein C, Olbers T, Wang M, Cluny NL, Bloom SR, Sharkey KA, Lutz TA, le Roux CW. Gastric bypass increases energy expenditure in rats. Gastroenterology. 2010 May;138(5):1845-53.

 

Kokkinos A, le Roux CW, Alexiadou K, Tentolouris N, Vincent RP, Kyriaki D, Perrea D, Ghatei MA, Bloom SR, Katsilambros N. Eating slowly increases the postprandial response of the anorexigenic gut hormones, peptide YY and glucagon-like peptide-1. J Clin Endocrinol Metab. 2010 Jan;95(1):333-7.

 

Glicksman C, Pournaras DJ, Wright M, Roberts R, Mahon D, Welbourn R, Sherwood R, Alaghband-Zadeh J, le Roux CW. Postprandial plasma bile acid responses in normal weight and obese subjects. Ann Clin Biochem. 2010 Sep;47(Pt 5):482-4.

Bueter M, Ashrafian H, Frankel AH, Tam FW, Unwin RJ, le Roux CW. Sodium and water handling after gastric bypass surgery in a rat model. Surg Obes Relat Dis. 2011 Jan-Feb;7(1):68-73.

 

Vincent RP, Goo CH, Wu PF, Delaney HL, le Roux CW. Influence of adherence to the national guidance on nutrition screening and dietitian referral on clinical outcomes of those requiring parenteral nutrition. J Hum Nutr Diet. 2010 Apr;23(2):190-3.

 

Elnenaei MO, Musto R, Alaghband-Zadeh J, Moniz C, le Roux CW. Postprandial bone turnover is independent of calories above 250 kcal. Ann Clin Biochem. 2010 Jul;47(Pt 4):318-20.

 

Bueter M, Löwenstein C, Ashrafian H, Hillebrand J, Bloom SR, Olbers T, Lutz T, le Roux CW. Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obes Surg. 2010 May;20(5):616-22.

 

Bueter M, Thalheimer A, le Roux CW, Wierlemann A, Seyfried F, Fein M. Upper gastrointestinal investigations before gastric banding. Surg Endosc. 2010 May;24(5):1025-30.

 

Pournaras DJ, Osborne A, Hawkins SC, Mahon D, Ghatei MA, Bloom SR, Welbourn R, le Roux CW. The gut hormone response following Roux-en-Y gastric bypass: cross-sectional and prospective study. Obes Surg. 2010 Jan;20(1):56-60.

 

Sathyapalan T, Cho L, Kilpatrick ES, le Roux CW, Coady AM, Atkin SL. Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2010 Mar;72(3):423-5.

 

Alexandraki KI, Kaltsas GA, le Roux CW, Fassnacht M, Ajodha S, Christ-Crain M, Akker SA, Drake WM, Edwards R, Allolio B, Grossman AB. Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study. Clin Endocrinol (Oxf). 2010 Mar;72(3):305-11.

 

Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW. A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis. Clin Gastroenterol Hepatol. 2009 Nov;7(11):1189-94.

 

Pournaras DJ, le Roux CW. After bariatric surgery what vitamins should be measured and what supplements should be given? Clin Endocrinol (Oxf). 2009 Sep;71(3):322-5.

 

Vincent RP, Aylwin SJ, le Roux CW. When the brakes came off: re-feeding oedema after deflation of a gastric band. Obes Surg. 2009 Oct;19(10):1468-70.

 

Vincent RP, Etogo-Asse FE, Dew T, Bernal W, Alaghband-Zadeh J, le Roux CW. Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment. Ann Clin Biochem. 2009 Nov;46(Pt 6):505-7.

 

Murray CD, le Roux CW, Emmanuel AV, Halket JM, Przyborowska AM, Kamm MA, Murray-Lyon IM. The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion. Appetite. 2008 Nov;51(3):747-50.

 

le Roux CW, Borg CM, Murphy KG, Vincent RP, Ghatei MA, Bloom SR. Supraphysiological doses of intravenous PYY(3-36) cause nausea, but no additional reduction in food intake. Ann Clin Biochem. 2008 Jan;45:93-5.

 

le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A, Lönroth H, Fändriks L, Ghatei MA, Bloom SR, Olbers T. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Annals of Surgery 2007 Nov;246(5):780-785.

 

Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG. Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels. Obes Surg. 2007 Sep;17(9):1193-8.

 

Germain N, Galusca B, le Roux CW, Bossu C, Ghatei MA, Lang F, Bloom SR, Estour B. Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin. Am J Clin Nutr. 2007 Apr;85(4):967-71.

 

Moran LJ, Noakes M, Clifton PM, Wittert GA, le Roux CW, Ghatei MA, Bloom SR, Norman RJ. Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome. Am J Clin Nutr. 2007 Dec;86(6):1603-10.

 

le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology. 2006 Jan;147(1):3-8

 

le Roux CW, Aylwin SJB, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR. Gut hormone profiles following bariatric surgery favour an anorectic state, facilitate weight loss and improve metabolic parameters. Annals of Surgery. 2006 Jan;243(1):108-14.

 

Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, le Roux CW, Thomas EL, Bell JD, Withers DJ. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 2006 Sep;4(3):223-33.

 

Murray CD, le Roux CW, Gouveia C, Bassett P, Ghatei MA, Bloom SR, Emmanuel AV, Gabe SM. The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients. Clin Nutr 2006 Aug;25(4):626-33.

 

Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG , Aylwin SJB. Progressive rise in gut hormones after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Brit J Surg. 2006 Jan 3;93(2):210-215

 

le Roux CW, Neary NM, Halsey TJ, Small CJ, Martinez-Isla AM, Ghatei MA, Theodorou NA, Bloom SR. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 2005 Aug;90(8):4521-4.

 

Patterson M, Murphy KG, le Roux CW, Ghatei MA, Bloom SR. Characterization of ghrelin-like immunoreactivity in human plasma. J Clin Endocrinol Metab. 2005 Apr;90(4):2205-11.

 

le Roux CW, Ghatei MA, Gibbs JS, Bloom SR. The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart. 2005 Feb;91(2):241-2.

 

le Roux CW, Patterson M, Vincent RP, Hunt C, Ghatei MA, Bloom SR. Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab. 2005 Feb;90(2):1068-71.

 

le Roux C, Murphy E, Hallam P, Lilburn M, Orlowska D, Lee P. Neuropsychometric outcome predictors for adults with maple syrup urine disease. J Inherit Metab Dis. 2006 Feb;29(1):201-2.

 

le Roux C, Murphy E, Lilburn M, Lee PJ. The longest-surviving patient with classical maple syrup urine disease. J Inherit Metab Dis. 2006 Feb;29(1):190-4.

 

Mulla A, le Roux C, Solito E, Buckingham JC. Correlation between the anti-inflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function. J Clin Endocrinol Metab. 2005 Jan;90(1):557-62.

 

Batterham RL, Cohen MA, Ellis S, le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR.  Inhibition of food intake in obese subjects by PYY3-36. New England Journal of Medicine, 2003 Sep 4;349(10):941-8.

 

le Roux CW, Mulla A, Meeran K. Pituitary carcinoma as a cause of acromegaly. New England Journal of Medicine, 2001, 35, 1645-1646

 

le Roux CW, Wilkinson SD, Pavitt DV, Muller BR, Alaghband-Zadeh J. A new antiglycolytic agent. Ann Clin Biochem. 2004 Jan;41(Pt 1):43-6.

le Roux CW , Chapman GA, Dhillo WS, Kong WM, Jones J, Alaghband-Zadeh J. Free cortisol index is better than serum total cortisol at determining HPA axis status in patients post surgery. J Clin Endocrinol Metab 2003 May;88(5):2045-8.

 

Batterham RL, le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR. Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab. 2003 Aug;88(8):3989-92.

 

Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, Frost GS, Ghatei MA, Bloom SR. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab. 2003 Oct;88(10):4696-701.

 

le Roux CW, Jenkins PJ, Grossman AB, Chew SL, Besser GM, Monson JP, Growth hormone replacement does not increase serum prostate specific antigen in hypopituitary men over 50. Eur J Endocrinology 2002 Jul;147(1):59-63

 

le Roux CW, Meeran K, Alaghband-Zadeh J. Is a 09:00 cortisol useful prior to a short synacthen test in outpatient assessment? Ann Clin Biochem 2002; 39: 148-150

 

le Roux CW, Sivakumaran S, Alaghband-Zadeh J, Dhillo W, Kong WM, Wheeler M,  Free cortisol index as surrogate marker for serum free cortisol. Ann Clin Biochem 2002;39(4):406-8.

 

Dhillo WS, Kong WM, le Roux CW, Alaghband-Zadeh J, Jones J, Carter G, Mendoza N, Meeran M, O’Shea D. Cortisol Binding Globulin is important in the interpretation of dynamic tests of the Hypothalamic-Pituitary-Adrenal axis. Eur J Endocrinology 2002, 146, 231-235

 

le Roux CW, Murphy E, Seed M. A retrospective assessment of the effectiveness of fenofibrate 267 mg on high-density lipoprotein cholesterol levels in patients attending a lipid clinic. Clin Ther. 2002 Jul;24(7):1154-60.

 

le Roux CW, Davison AG, Besser GM, Pinching AJ. Cushing’s syndrome secondary to inhaled corticosteroids mimicking HIV-associated lipodystrophy; HIV Medicine (2001) 2, 133-135

 

Seed M, Mendalo R, le Roux CW. The treatment of hyperlipidaemia in post menopausal women, Journal of the British Menopause Society 2001 March: 28-32

 

le Roux CW, Vermaak GA, Pitout MJ, Effect of Anabolic Steroid: Effect of oxymetholone on the reproductive potential of male rats; Molecular Andrology 1995;vol 7/1-2: 1-3

 

Invited review articles

 

Al-Najim W, Docherty NG, le Roux CW. Food Intake and Eating Behavior After Bariatric Surgery. Physiol Rev. 2018 Jul 1;98(3):1113-1141. doi: 10.1152/physrev.00021.2017. PMID: 29717927

 

Miras AD, le Roux CW. Surgery: The new gold-standard - medical gastric bypass. Nat Rev Endocrinol. 2018 May;14(5):257-258. doi: 10.1038/nrendo.2018.28. Epub 2018 Mar 16. No abstract available. PMID: 29546872

 

Jain AK, le Roux CW, Puri P, Tavakkoli A, Gletsu-Miller N, Laferrère B, Kellermayer R, DiBaise JK, Martindale RG, Wolfe BM. Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut. JPEN J Parenter Enteral Nutr. 2018 Feb;42(2):279-295. doi: 10.1002/jpen.1121. Review. PMID: 29443403

 

Mingrone G, Bornstein S, Le Roux CW. Optimisation of follow-up after metabolic surgery. Lancet Diabetes Endocrinol. 2018 Jan 29. pii: S2213-8587(17)30434-5. doi: 10.1016/S2213-8587(17)30434-5. PMID: 29396249

 

le Roux CW, Heneghan HM. Bariatric Surgery for Obesity. Med Clin North Am. 2018 Jan;102(1):165-182. doi: 10.1016/j.mcna.2017.08.011. Review. PMID: 29156184

 

Murphy CF, Docherty NG, le Roux CW. Liraglutide: another reason to target prediabetes? Oncotarget. 2017 Nov 1;8(59):99203-99204. doi: 10.18632/oncotarget.22256. eCollection 2017 Nov 21. PMID: 29245886

 

Sinclair P, Docherty N, le Roux CW. Metabolic Effects of Bariatric Surgery. Clin Chem. 2017 Nov 21. pii: clinchem.2017.272336. doi: 10.1373/clinchem.2017.272336. [Epub ahead of print] Review. PMID: 29162562

 

Koliaki C, Liatis S, le Roux CW, Kokkinos A. The role of bariatric surgery to treat diabetes: current challenges and perspectives. BMC Endocr Disord. 2017 Aug 10;17(1):50. doi: 10.1186/s12902-017-0202-6. Review. PMID: 28797248

 

Gero D, Steinert RE, le Roux CW, Bueter M. Do Food Preferences Change After Bariatric Surgery? Curr Atheroscler Rep. 2017 Sep;19(9):38. doi: 10.1007/s11883-017-0674-x. Review. PMID: 28779431

 

Kapoor N, Al-Najim W, le Roux CW, Docherty NG. Shifts in Food Preferences After Bariatric Surgery: Observational Reports and Proposed Mechanisms. Curr Obes Rep. 2017 Jul 11. doi: 10.1007/s13679-017-0270-y. [Epub ahead of print] Review. PMID: 28699145

 

Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017 Apr;5(7):161. doi: 10.21037/atm.2017.03.107. Review. PMID: 28480197

 

Murphy CF, le Roux CW. The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy. Int J Mol Sci. 2016 Dec 26;18(1). pii: E35. doi: 10.3390/ijms18010035. Review. PMID: 28035969

 

Giblin L, McGrath BA, Murray BA, le Roux CW, Docherty NG, McSweeney PL, Kelly AL. Letter to the Editor Regarding Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction following Bariatric Surgery. Obes Surg. 2016 Dec 21. doi: 10.1007/s11695-016-2508-2. PMID: 28000090

 

Nair M, le Roux CW, Docherty NG. Measuring changes in renal function after bariatric surgery: Why estimated glomerular filtration rate is not good enough. Surg Obes Relat Dis. 2016 Dec;12(10):1897-1898. doi: 10.1016/j.soard.2016.03.027. PMID: 27998545

 

Elliott JA, le Roux CW. Type 2 diabetes with BMI<30 kg/m2: Can we predict success of metabolic surgery? Surg Obes Relat Dis. 2016 Aug;12(7):1363-1365. doi: 10.1016/j.soard.2016.03.012. PMID: 27130137

 

Gorman DM, le Roux CW, Docherty NG. The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both? Diabetes Metab J. 2016 Oct;40(5):354-364. Review. PMID: 27766242

 

Nair M, le Roux CW, Docherty NG. Mechanisms underpinning remission of albuminuria following bariatric surgery. Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):366-72. doi: 10.1097/MED.0000000000000279. PMID: 27584009

 

Bächler T, le Roux CW, Bueter M. How do patients' clinical phenotype and the physiological mechanisms of the operations impact the choice of bariatric procedure?

Clin Exp Gastroenterol. 2016 Jul 22;9:181-9. doi: 10.2147/CEG.S87205. eCollection 2016. Review. PMID: 27524917

 

Melvin A, le Roux CW, Docherty NG. The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight. Curr Atheroscler Rep. 2016 Aug;18(8):49. PMID: 27324637

 

Cohen RV, Shikora S, Petry T, Caravatto PP, le Roux CW. The Diabetes Surgery Summit II Guidelines: a Disease-Based Clinical Recommendation. Obes Surg. 2016 Aug;26(8):1989-91. PMID: 27189354

 

Hansen TT, Jakobsen TA, Nielsen MS, Sjödin A, le Roux CW, Schmidt JB. Hedonic Changes in Food Choices Following Roux-en-Y Gastric Bypass. Obes Surg. 2016 May 12. [Epub ahead of print] Review. PMID: 27173820

 

Docherty NG, le Roux CW. Reconfiguration of the small intestine and diabetes remitting effects of Roux-en-Y gastric bypass surgery. Curr Opin Gastroenterol. 2016 Mar;32(2):61-6. doi: 10.1097/MOG.0000000000000241. PMID: 26839962

 

Spector AC, le Roux CW, Munger SD, Travers SP, Sclafani A, Mennella JA. Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health. JPEN J Parenter Enteral Nutr. 2015 Nov 23. pii: 0148607115617438. [Epub ahead of print] PMID: 26598504

 

Abdeen G, le Roux CW. Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review. Obes Surg. 2015 Nov 3. [Epub ahead of print] PMID: 26530712

 

Docherty NG, le Roux CW. Physiological adaptations following Roux-en-Y gastric bypass and the identification of targets for bariatric mimetic pharmacotherapy. Curr Opin Pharmacol. 2015 Oct 19;25:23-29. doi: 10.1016/j.coph.2015.09.012. [Epub ahead of print] Review. PMID: 26496012

 

Pournaras DJ, le Roux CW. Bariatric Surgery and Decreasing Vascular Risk. Angiology. 2015 Oct 18. pii: 0003319715612608. [Epub ahead of print] Review. PMID: 26483567

 

Scholtz S, Goldstone AP, le Roux CW. Changes in Reward after Gastric Bypass: the Advantages and Disadvantages. Curr Atheroscler Rep. 2015 Oct;17(10):61. doi: 10.1007/s11883-015-0534-5. PMID: 26358733

 

Docherty NG, Canney AL, le Roux CW. Weight loss interventions and progression of diabetic kidney disease. Curr Diab Rep. 2015 Aug;15(8):625. doi: 10.1007/s11892-015-0625-2. PMID: 26122095

 

Elliott JA, le Roux CW, How long should we make the biliopancreatic limb during Roux-en-Y gastric bypass? Surg Obes Relat Dis. 2015 May 5. pii: S1550-7289(15)00139-2. doi: 10.1016/j.soard.2015.04.020. [Epub ahead of print] PMID: 26112180

 

Tham JC, le Roux CW, Docherty NG. Cardiovascular, renal and overall health outcomes after bariatric surgery. Curr Cardiol Rep. 2015 May;17(5):34. doi: 10.1007/s11886-015-0588-6. PMID: 25894801

 

Jackson S, le Roux CW, Docherty NG. Bariatric surgery and microvascular complications of type 2 diabetes mellitus. Curr Atheroscler Rep. 2014 Nov;16(11):453. doi: 10.1007/s11883-014-0453-x.

 

Docherty NG, le Roux CW. Physiological and pathophysiological signalling between the gut and the kidney: role in diabetic kidney disease. Exp Physiol. 2014 Sep;99(9):1138-9. doi: 10.1113/expphysiol.2014.078162.

 

le Roux CW, Bueter M. The physiology of altered eating behaviour after Roux-en-Y gastric bypass. Exp Physiol. 2014 Sep;99(9):1128-32. doi: 10.1113/expphysiol.2014.078378.

 

Docherty NG, le Roux CW. Improvements in The Metabolic Milieu following Roux-en-Y Gastric Bypass and the Arrest of Diabetic Kidney Disease.

Exp Physiol. 2014 Aug 1. [Epub ahead of print]

 

Buhmann H, le Roux CW, Bueter M. The gut-brain axis in obesity. Best Pract Res Clin Gastroenterol. 2014 Aug;28(4):559-71. doi: 10.1016/j.bpg.2014.07.003. Epub 2014 Jul 11. Review.

 

Tham JC, Howes N, le Roux CW. The role of bariatric surgery in the treatment of diabetes. Ther Adv Chronic Dis. 2014 May;5(3):149-57.

 

Miras AD, le Roux CW. Metabolic surgery: shifting the focus from glycaemia and weight to end-organ health. Lancet Diabetes Endocrinol. 2014 Feb;2(2):141-51.

 

Pournaras DJ, le Roux CW. Can we predict diabetes remission after weight-loss surgery? Lancet Diabetes Endocrinol. 2014 Jan;2(1):4-6. doi: 10.1016/S2213-8587(13)70108-6. Epub 2013 Sep 13. No abstract available.

 

Miras AD, le Roux CW. Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery? Int J Obes (Lond). 2014 Mar;38(3):325-33.

 

Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW. The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv73-82.

 

Pournaras DJ, le Roux CW. Preventing type 2 diabetes, CVD, and mortality: surgical versus non-surgical weight loss strategies. Curr Atheroscler Rep. 2013 Nov;15(11):367. doi: 10.1007/s11883-013-0367-z.

 

Papamargaritis D, Miras AD, le Roux CW. Influence of diabetes surgery on gut hormones and incretins. Nutr Hosp. 2013 Mar;28 Suppl 2:95-103. doi: 10.3305/nh.2013.28.sup2.6719.

 

Chuah LL, Papamargaritis D, Pillai D, Krishnamoorthy A, le Roux CW. Morbidity and mortality of diabetes with surgery. Nutr Hosp. 2013 Mar;28 Suppl 2:47-52. doi: 10.3305/nh.2013.28.sup2.6713.

 

Chuah LL, le Roux CW. Management of patients with type 2 diabetes before and after bariatric surgery: evolution and microvascular complications. Nutr Hosp. 2013 Mar;28 Suppl 2:17-22. doi: 10.3305/nh.2013.28.sup2.6709.

 

Neff KJ, le Roux CW. Bariatric Surgery: The Indications in Metabolic Disease. Dig Surg. 2013 Jul 6. [Epub ahead of print]

 

Miras AD, le Roux CW. Mechanisms underlying weight loss after bariatric surgery. Nat Rev Gastroenterol Hepatol. 2013 Oct;10(10):575-84. doi: 10.1038/nrgastro.2013.119. Epub 2013 Jul 9.

 

Dixon JB, le Roux CW, Rubino F, Zimmet P. Bariatric surgery for type 2 diabetes. Lancet. 2012 Jun 16;379(9833):2300-11. Review.

Elliott JA, Patel VM, Kirresh A, Ashrafian H, le Roux CW, Olbers T, Athanasiou T, Zacharakis E. Fast-track laparoscopic bariatric surgery: a systematic review. Updates Surg. 2013 Feb 1.

Neff KJ, Olbers T, le Roux CW. Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes. BMC Med. 2013 Jan 10;11(1):8.

Neff KJ, O'Shea D, le Roux CW. Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: a Signpost to a new frontier. Curr Diabetes Rev. 2013 Mar 1;9(2):93-101.

Neff KJ, le Roux CW. Bariatric surgery: a best practice article. J Clin Pathol. 2012 Nov 21. [Epub ahead of print]

Papamargaritis D, Panteliou E, Miras AD, le Roux CW. Mechanisms of weight loss, diabetes control and changes in food choices after gastrointestinal surgery. Curr Atheroscler Rep. 2012 Dec;14(6):616-23.

Bueter M, le Roux CW. Gastrointestinal hormones, energy balance and bariatric surgery. Int J Obes (Lond). 2011 Sep;35 Suppl 3:S35-9. doi: 10.1038/ijo.2011.146.

Seyfried F, le Roux CW, Bueter M. Lessons learned from gastric bypass operations in rats. Obes Facts. 2011;4 Suppl 1:3-12.

Ashrafian H, le Roux CW, Rowland SP, Ali M, Cummin AR, Darzi A, Athanasiou T. Metabolic surgery and obstructive sleep apnoea: the protective effects of bariatric procedures. Thorax. 2011 Jun 27. [Epub ahead of print]

Ashrafian H, Athanasiou T, le Roux CW. Heart remodelling and obesity: the complexities and variation of cardiac geometry. Heart. 2011 Feb;97(3):171-2.

Pournaras DJ, le Roux CW. Ghrelin and metabolic surgery. Int J Pept. 2010;2010. pii: 217267.

Pournaras DJ, le Roux CW. The effect of bariatric surgery on gut hormones that alter appetite. Diabetes Metab. 2009 Dec;35(6 Pt 2):508-12. Review.

 

Bueter M, Ashrafian H, le Roux CW. Mechanisms of weight loss after gastric bypass and gastric banding. Obes Facts. 2009;2(5):325-31.

 

Miras AD, le Roux CW. Bariatric surgery and taste: novel mechanisms of weight loss. Curr Opin Gastroenterol. 2009 Nov 6.

 

Bueter M, le Roux CW. Sir David Cuthbertson Medal Lecture. Bariatric surgery as a model to study appetite control. Proc Nutr Soc. 2009 Aug;68(3):227-33.

 

Pournaras DJ, le Roux CW. Obesity, Gut Hormones, and Bariatric Surgery.

World J Surg. 2009 Jun 9. [Epub ahead of print]

 

Bueter M, Ahmed A, Ashrafian H, le Roux CW. Bariatric surgery and hypertension.

Surg Obes Relat Dis. 2009 Apr 7. [Epub ahead of print]

 

Murray CDR, le Roux CW, Fat vs Fat - is NAPE the next magic bullet? Cell Science Reviews 2009 Vol 5 No 3

 

Ashrafian H, le Roux CW, Darzi A, Athanasiou T. The Effects of Bariatric Surgery on Cardiovascular Function, Circulation 2008 Nov 11;118(20):2091-102.

 

Tadross JA, le Roux CW. The mechanisms of weight loss after bariatric surgery. Int J Obes (Lond). 2009 Apr;33 Suppl 1:S28-32.

 

Vincent RP, Ashrafian H, le Roux CW. Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity. Nat Clin Pract Gastroenterol Hepatol. 2008 May;5(5):268-77.

 

Vincent RP, le Roux CW. The satiety hormone peptide YY as a regulator of appetite. J Clin Pathol. 2008 May;61(5):548-52.

 

Thompson GR; Barbir  M, Davies D, Dobral P, Gesinde M, Livingston M, Mandry P, Matthews S, Neuwirth C, Pottle A, le Roux C, Scullard D, Stokes G, Tyler C, Watkins S. Recommendations for the use of LDL apheresis. Atherosclerosis. 2008 Feb 19. [Epub ahead of print]

 

Vasilakopoulou A, le Roux CW. Could a virus contribute to weight gain? Int J Obes (Lond). 2007 Apr 10;

 

Vincent RP, le Roux CW.  Changes in gut hormones after bariatric surgery.

Clin Endocrinol (Oxf). 2007 Dec 20;

 

Vincent RP, le Roux CW. New agents in development for the management of obesity.

Int J Clin Pract. 2007 Dec;61(12):2103-12.

 

le Roux CW, Bloom SR. Why do patients lose weight after Roux-en-Y gastric bypass? J Clin Endocrinol Metab. 2005 Jan;90(1):591-2.

 

le Roux CW,  Bloom SR. Peptide YY, appetite and food intake. Proc Nutr Soc. 2005 May;64(2):213-6. Review.

 

le Roux CW, Bloom SR. Clinical authorization: what is best for the patient? Ann Clin Biochem 2003; 40: 113-114

 

Book chapters

 

le Roux CW, Bangert SK. Nutritional disorders and their management in Clinical Biochemistry edited by William J Marshall and Stephen K Bangert, Second Edition, Churchill Livingstone ISBN 978-0-443-10186-1

 

le Roux C. Fast Facts Hyperlipidaemia. Evidence-based Cardiovascular Medicine; 2004 Volume 8(2):196-196

 

Park A, le Roux C, Frost P, Bloom S; Career focus: Chemical Pathology; BMJ classified 2001 Sept 16: 2-3